Recent advances in electro-organic chemistry involving miniaturization, integration, and combinatorial chemistry were reviewed. Microelectrode array technology for site-selective electro-organic reactions and addressable libraries provides a direct and unlabeled method for measuring small-molecule–protein interactions. Electrochemical systems using solid-supported bases and acids (“site separation”) can realize electrolysis without the addition of supporting electrolytes. Well-designed “bipolar electrodes” have enabled the production of patterned gradient polymer brushes and microfibers. For the display of combinatorial organic electrochemistry, batch and flow electrolysis systems for the optimization and screening of electro-organic reactions as well as the building of chemical libraries for organic compounds are described.

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有机电化学的小型化和组合方法

综述了涉及小型化，集成化和组合化学的有机化学的最新进展。用于位置选择性电子有机反应和可寻址文库的微电极阵列技术为测量小分子与蛋白质的相互作用提供了一种直接且未标记的方法。使用固体支持的碱和酸的电化学系统（“位点分离”）可以实现电解，而无需添加支持电解质。精心设计的“双极电极”使图案化的梯度聚合物电刷和超细纤维的生产成为可能。为了展示组合有机电化学，描述了用于优化和筛选有机电反应以及建立有机化合物化学库的间歇和流式电解系统。