Dendrimer‐based supramolecular hydrogels have gained attention in biomedical fields. While biocompatible dendrimers were used to prepare hydrogels via physical and/or chemical crosslinking, smart functions such as pH and molecular control remain undeveloped. Here, we present polyglycerol dendrimer‐based supramolecular hydrogel formation induced by a specific interaction between the polyglycerol dendrimer and an amino group of glycol chitosan. Gelation was achieved by mixing the two aqueous solutions. Hydrogel formation was controlled by varying the polyglycerol dendrimer generation. The hydrogel showed pH‐dependent swelling; strongly acidic conditions induced degradation via dissociation of the specific interaction. It also showed unique l‐arginine‐responsive degradation capability due to competitive exchange of the amino groups of glycol chitosan and l‐arginine. These polyglycerol dendrimer‐based supramolecular characteristics allow multimodal application in smart biomaterials.

中文翻译：

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基于聚甘油树枝状大分子特定氨基基团识别的超分子水凝胶

基于树枝状大分子的超分子水凝胶在生物医学领域得到了关注。尽管使用生物相容性树状聚合物通过物理和/或化学交联制备水凝胶，但诸如pH和分子控制等智能功能仍未开发。在这里，我们介绍了由聚甘油树枝状大分子与乙二醇壳聚糖的氨基之间的特定相互作用所诱导的基于聚甘油树枝状大分子的超分子水凝胶形成。通过混合两种水溶液来实现胶凝。通过改变聚甘油树状聚合物的生成来控制水凝胶的形成。水凝胶显示pH依赖性溶胀；强酸性条件通过特定相互作用的解离诱导降解。这也显示出独特的升乙二醇壳聚糖和l精氨酸的氨基竞争性交换导致的精氨酸响应降解能力。这些基于聚甘油树状大分子的超分子特性允许在智能生物材料中进行多峰应用。