Spiro-oxindoles, epi-Spirotryprostatin A and its analogues were prepared from a tactical combination of cascade catalytic bimetallic Pd (0)/Ag(I), intramolecular Heck and subsequent imine → azomethine ylide → 1,3-Dipolar cycloaddition reactions. The cascade features in situ generation of azomethine ylides and dipolarophiles and produces two new rings together with three stereocentres in good to excellent yields.

中文翻译：

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催化双金属[Pd（0）/ Ag（I）Heck-1,3-偶极环加成级联反应访问螺-羟吲哚。伴随原位代甲亚胺叶立德和亲偶极的

从级联催化双金属Pd（0）/ Ag（I），分子内Heck以及随后的亚胺→亚甲次基叶立德→ 1,3-偶极环加成反应的战术组合制备螺-羟吲哚，epi-Spirotryprostatin A及其类似物。级联反应具有原位生成甲亚胺基亚胺和双极性亲核试剂的特性，并产生两个新的环以及三个立体中心，收率好至极好。