The vinyl ether benzyloxycarbonyl (VeZ) protecting group is selectively cleaved by treatment with tetrazines via an inverse electron-demand Diels–Alder reaction. This represents a new orthogonal protecting group for solid-phase peptide synthesis, with Fmoc-Lys(VeZ)-OH as a versatile alternative to Fmoc-Lys(Alloc)-OH and Fmoc-Lys(Dde)-OH, as demonstrated by the synthesis of two biologically relevant cyclic peptides.

中文翻译：

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四嗪不稳定的乙烯基醚苄氧羰基保护基（VeZ）：固相肽化学的正交工具

乙烯基醚苄氧基羰基（VeZ）保护基可通过反电子需求的Diels-Alder反应用四嗪处理选择性地裂解。这代表了固相肽合成的一个新的正交保护基，Fmoc-Lys（VeZ）-OH是Fmoc-Lys（Alloc）-OH和Fmoc-Lys（Dde）-OH的多用途替代品，合成两个生物学上相关的环肽。