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Manganese-Catalyzed Direct Conversion of Ester to Amide with Liberation of H2
Organic Letters ( IF 5.2 ) Pub Date : 2018-05-23 00:00:00 , DOI: 10.1021/acs.orglett.8b01305
Akash Mondal 1 , Murugan Subaramanian 1 , Avanashiappan Nandakumar 1 , Ekambaram Balaraman 1
Affiliation  

A simple and efficient Mn-catalyzed acylation of amines is achieved using both acyl and alkoxy functions of unactivated esters with the liberation of molecular hydrogen as a sole byproduct. The present protocol provides an atom-economical and sustainable route for the synthesis of amides from esters by employing an earth-abundant manganese salt and inexpensive phosphine-free tridentate ligand.

中文翻译:

释放H 2的锰催化酯直接转化为酰胺

使用未活化的酯的酰基和烷氧基官能团,同时释放分子氢作为唯一的副产物,可实现胺的简单有效的Mn催化酰化反应。本方案提供了一种原子经济且可持续的途径,可通过使用富含地球的锰盐和廉价的不含膦的三齿配体从酯合成酰胺。
更新日期:2018-05-23
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