当前位置: X-MOL 学术Neurosci Biobehav Rev › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
The neural circuitry of restricted repetitive behavior: Magnetic resonance imaging in neurodevelopmental disorders and animal models
Neuroscience & Biobehavioral Reviews ( IF 8.2 ) Pub Date : 2018-05-23 , DOI: 10.1016/j.neubiorev.2018.05.022
B.J. Wilkes , M.H. Lewis

Restricted, repetitive behaviors (RRBs) are patterns of behavior that exhibit little variation in form and have no obvious function. RRBs although transdiagonstic are a particularly prominent feature of certain neurodevelopmental disorders, yet relatively little is known about the neural circuitry of RRBs. Past work in this area has focused on isolated brain regions and neurotransmitter systems, but implementing a neural circuit approach has the potential to greatly improve understanding of RRBs. Magnetic resonance imaging (MRI) is well-suited to studying the structural and functional connectivity of the nervous system, and is a highly translational research tool. In this review, we synthesize MRI research from both neurodevelopmental disorders and relevant animal models that informs the neural circuitry of RRB. Together, these studies implicate distributed neural circuits between the cortex, basal ganglia, and cerebellum. Despite progress in neuroimaging of RRB, there are many opportunities for conceptual and methodological improvement. We conclude by suggesting future directions for MRI research in RRB, and how such studies can benefit from complementary approaches in neuroscience.



中文翻译:

重复行为受限的神经回路:神经发育障碍和动物模型中的磁共振成像

限制性重复行为(RRB)是行为形式,表现出形式上的细微变化,并且没有明显的功能。尽管RRBs是透神经激动的,在某些神经发育障碍中尤为突出,但对RRBs的神经回路知之甚少。该领域过去的工作集中在孤立的大脑区域和神经递质系统上,但是实施神经回路方法有可能极大地增进对RRB的理解。磁共振成像(MRI)非常适合研究神经系统的结构和功能连接性,并且是一种高度转换的研究工具。在这篇综述中,我们综合了神经发育障碍和相关动物模型的MRI研究,这些研究为RRB的神经回路提供了信息。一起,这些研究暗示了皮层,基底神经节和小脑之间的分布式神经回路。尽管RRB的神经影像学取得了进步,但在概念和方法上仍有许多改进的机会。最后,我们建议了RRB的MRI研究的未来方向,以及这些研究如何从神经科学的补充方法中受益。

更新日期:2018-05-23
down
wechat
bug