A synthetic strategy for accessing protoaculeine B (1), the N-terminal amino acid of the highly modified peptide toxin aculeine, was developed via the synthesis of the fully protected natural homologue of 1 with a 12-mer poly(propanediamine). The synthesis of mono(propanediamine) analog 2, as well as core amino acid 3, was demonstrated by this strategy. New amino acid 3 induced convulsions in mice; however, compound 2 showed no such activity.

中文翻译：

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Ac子碱的研究：完全保护的原ac子碱B，Ac草碱B的N末端氨基酸的合成策略

通过合成具有12-mer聚丙二胺1的完全受保护的天然同源物，开发了一种用于获得原球泡蛋白B（1）（高度修饰的肽毒素球泡蛋白的N末端氨基酸）的合成策略。该策略证明了单（丙二胺）类似物2以及核心氨基酸3的合成。新的氨基酸3诱发小鼠惊厥；但是，化合物2没有这种活性。