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Rhodium-Catalyzed Asymmetric Dearomative [4 + 3]-Cycloaddition of Vinylindoles with Vinyldiazoacetates: Access to Cyclohepta[b]indoles
Organic Letters ( IF 5.2 ) Pub Date : 2018-05-23 00:00:00 , DOI: 10.1021/acs.orglett.8b01353 Guangyang Xu 1 , Long Chen 1 , Jiangtao Sun 1
Organic Letters ( IF 5.2 ) Pub Date : 2018-05-23 00:00:00 , DOI: 10.1021/acs.orglett.8b01353 Guangyang Xu 1 , Long Chen 1 , Jiangtao Sun 1
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A rhodium-catalyzed enantioselective formal [4 + 3]-cycloaddition of vinylindoles with vinyldiazoacetates has been developed, affording the dearomative cyclization products containing a newly formed seven-membered ring in up to 99% ee. Rh2(S-DOSP)4 has been proven to be the best catalyst for the cycloaddition of 3-vinylindoles with vinyldiazoacetates, whereas Rh2(S-TCPTTL)4 has enhanced the enantioselectivity for 2-vinylindoles.
中文翻译：
铑催化的乙烯基吲哚乙酸与乙烯基吲哚的不对称脱芳香性[4 + 3]-环加成反应：获得环庚基[ b ]吲哚
乙烯基吲哚与乙烯基重氮乙酸酯的铑催化的对映体选择性[4 + 3]-环加成反应已经开发出来，提供了脱芳香环化产物，该产物含有高达99％ee的新形成的七元环。Rh 2（S -DOSP）4被证明是3-乙烯基吲哚与乙烯基重氮乙酸酯环加成的最佳催化剂，而Rh 2（S -TCPTTL）4增强了2-乙烯基吲哚的对映选择性。
更新日期：2018-05-23
中文翻译：
铑催化的乙烯基吲哚乙酸与乙烯基吲哚的不对称脱芳香性[4 + 3]-环加成反应：获得环庚基[ b ]吲哚
乙烯基吲哚与乙烯基重氮乙酸酯的铑催化的对映体选择性[4 + 3]-环加成反应已经开发出来，提供了脱芳香环化产物，该产物含有高达99％ee的新形成的七元环。Rh 2（S -DOSP）4被证明是3-乙烯基吲哚与乙烯基重氮乙酸酯环加成的最佳催化剂，而Rh 2（S -TCPTTL）4增强了2-乙烯基吲哚的对映选择性。
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