Herein we report that a preferable inhibition of the nucleation phase of Aβ42, related to the formation of toxic oligomers, by triterpenoids from medicinal herbs originates from a salt bridge of their carboxy groups with Lys16 and 28 in Aβ42. Such a direct interaction targeting the monomer, dimer, and trimer suppressed further oligomerization. In contrast, the corresponding congeners without carboxy groups failed to do so.

中文翻译：

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三萜类化合物的羧基在抑制形成有毒低聚物所需的淀粉样蛋白β42的成核中的作用†

本文中我们报道，来自草药的三萜类化合物对Aβ42的成核相的优选抑制作用与毒性低聚物的形成有关，这是由于它们的羧基与Aβ42中的Lys16和28形成了盐桥。这种靶向单体，二聚体和三聚体的直接相互作用抑制了进一步的低聚。相反，没有羧基的相应同类物却没有这样做。