The term metastasis is widely used to describe the endpoint of the process by which tumour cells spread from the primary location to an anatomically distant site. Achieving successful dissemination is dependent not only on the molecular alterations of the cancer cells themselves, but also on the microenvironment through which they encounter. Here, we reviewed the molecular alterations of metastatic gastric cancer (GC) as it reflects a large proportion of GC patients currently seen in clinic. We hope that further exploration and understanding of the multistep metastatic cascade will yield novel therapeutic targets that will lead to better patient outcomes.

中文翻译：

---

转移性胃癌中癌细胞和肿瘤微环境的分子变化。

术语转移广泛用于描述肿瘤细胞从原发部位扩散到解剖学遥远部位的过程终点。成功的传播不仅取决于癌细胞本身的分子变化，还取决于它们遇到的微环境。在这里，我们回顾了转移性胃癌（GC）的分子变化，因为它反映了当前在临床上见过的大部分GC患者。我们希望对多步转移级联的进一步探索和理解将产生新的治疗靶标，从而带来更好的患者预后。