As more evidence emerges supporting the possibility that nonsteroidal anti‐inflammatory drugs, especially aspirin (acetyl salicylic acid), might have a role in the prevention and management of certain types of cancer, there have been several attempts to fabricate salicylic acid‐based polymers that can be employed in the targeted therapy of tumors. The primary disadvantage so far has been in use of nontherapeutic polymeric backbones that constitute the majority of the therapeutic particle's size. The focus of this research is the creation of a biodegradable polymer consisting only of salicylic acid, and its use as the main building block in targeted nanotherapeutics that would consequently provide both high local dose and sustained release of the active moiety. This work demonstrates the synthesis and degradation of polysalicylates, and modulation of their size and hydrolytic stability through the formation of nanostructures.

中文翻译：

---

由水杨酸构建的可降解聚合物和纳米颗粒

随着越来越多的证据支持非甾体类抗炎药，尤其是阿司匹林（乙酰水杨酸）可能在某些类型的癌症的预防和控制中发挥作用，人们进行了数种尝试来制造基于水杨酸的聚合物，可用于肿瘤的靶向治疗。迄今为止，主要的缺点是使用了非治疗性聚合物主链，该主链构成了治疗颗粒尺寸的大部分。这项研究的重点是创建仅由水杨酸组成的可生物降解的聚合物，并将其用作靶向纳米治疗剂的主要组成部分，从而可提供高局部剂量和活性成分的持续释放。这项工作证明了聚水杨酸酯的合成和降解，