A new and efficient synthesis of fully substituted 2,5-dihydrothiophenes by a sequential one-pot four component reaction between primary amines, β-ketoesters, aryl isothiocyanates and 1,2-diaza-1,3-dienes (DDs) is reported. A careful selection of the starting materials enables the choice of up to six different variations in the architecture of the final products. Furthermore, the acidic treatment of the so-obtained 2,5-dihydrothiophenes furnishes the corresponding 5-amino thiophene-2,4-dicarboxylates.

中文翻译：

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通过新颖的顺序多组分反应 组装完全取代的2,5-二氢噻吩†

据报道，通过伯胺，β-酮酸酯，芳基异硫氰酸酯和1,2-二氮杂-1,3-二烯（DDs）之间的顺序一锅四组分反应，可以有效地合成完全取代的2,5-二氢噻吩。仔细选择原材料，可以在最终产品的结构中选择多达六个不同的变化。此外，如此获得的2，5-二氢噻吩的酸性处理提供了相应的5-氨基噻吩-2，4-二羧酸酯。