A novel 1,4-Phenyl radical rearrangement (1,4-PhRR) is described in a typical Barton decarboxylation procedure. While carrying out this reaction in presence of a N,N-disubstituted β-amino acid derivative, the decarboxyphenyl rearranged derivative is obtained, as well as in presence of β-N,N-acylamide. On the other hand, secondary amines give the β-lactam derivative without rearrangement, as well as N-Fmoc derivatives give the normal decarboxylation reaction. In regards of amines which are far away from the carboxylic group, such as δ-amino acid derivatives, the reaction occur through a typical Barton decarboxylation without rearrangement. The diversity of the reaction proves synthetic usefulness paving the way to interesting biologically active compounds.

在典型的Barton脱羧程序中描述了一种新颖的1,4-苯基自由基重排（1,4-PhRR）。在N，N-二取代的β-氨基酸衍生物的存在下进行该反应时，获得脱羧苯基重排的衍生物，以及在β - N，N-酰基酰胺的存在下。另一方面，仲胺产生β-内酰胺衍生物而没有重排，而N- Fmoc衍生物产生正常的脱羧反应。关于远离羧基的胺，例如δ-氨基酸衍生物，该反应通过典型的Barton脱羧而没有重排发生。反应的多样性证明了合成的有用性，为有趣的生物活性化合物铺平了道路。