Neurodegeneration-associated hallmarks include an abundance of protein aggregates and amelioration of mitochondrial function. Despite the knowledge of molecular counteracting mechanisms, the molecular dialogue between protein aggregate accumulation and aberrant mitochondrial import is poorly understood. Recent work unraveled a novel role for the mitochondrial import machinery in regulating cytosolic proteostasis.

中文翻译：

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过多的MAGIC会导致线粒体吞噬吗？

与神经退行性疾病有关的标志包括大量的蛋白质聚集和线粒体功能的改善。尽管了解分子抵消机制，但对蛋白质聚集体积累与异常线粒体输入之间的分子对话知之甚少。最近的工作揭示了线粒体导入机制在调节胞质蛋白稳态中的新作用。