A series of tabletop models was built to demonstrate the interactions between a fictional cell-surface receptor, the receptor’s natural ligand, and eight potential therapeutic agents. Students assessed the eight therapeutic agents as agonists, antagonists, or neither agonists nor antagonists, first as a pencil-and-paper exercise and then subsequently using the three-dimensional models. Students found the activity to be engaging and were more accurately able to identify the correct roles of the agents when using the models.

中文翻译：

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使用分子模型评估细胞表面受体的激动剂和拮抗剂

建立了一系列桌面模型来演示虚构的细胞表面受体，受体的天然配体和八种潜在治疗剂之间的相互作用。学生首先将这八种治疗剂评估为激动剂，拮抗剂，或者既不是激动剂也不是拮抗剂，首先是纸笔练习，然后再使用三维模型。学生发现该活动很有趣，并且在使用模型时能够更准确地确定代理商的正确角色。