The key role of oxidative stress in alcoholic liver disease (ALD) has been established by the large body of evidence from previous studies. Excessive consumption of ethanol induces the production of a variety of reactive oxygen species (ROS) in the liver, such as superoxide, H₂O₂, and hydroxyl radical. These products activate oxidant-sensitive signaling cascades and modulators of apoptosis. Because ROS accumulation is closely related to ALD, a number of studies have investigated the benefits of antioxidants. Recent studies demonstrated that polyphenol chlorogenic acid (CGA) has antioxidant properties and health benefits, such as reduction of relative risk of cardiovascular diseases and hepatoprotective effects against acetaminophen toxicity. However, the protective effects of CGA against ALD have not been studied in detail. We hypothesize that CGA plays a role in preventing ALD through its antioxidant properties. In this study, we investigated the protective effects of CGA against liver injuries in vivo. Reduced alcohol-induced-steatosis, apoptotic cell death, and fibrosis due to reduced levels of oxidative stress were observed. These findings suggest that CGA treatment can be an effective approach to attenuate ALD through the suppression of oxidative stress.

氧化应激在酒精性肝病（ALD）中的关键作用已被先前研究的大量证据所证实。过量消耗乙醇会导致肝脏中产生多种活性氧（ROS），例如超氧化物，H ₂ O ₂和羟基自由基。这些产物激活了对氧化剂敏感的信号级联和细胞凋亡的调节剂。由于ROS的积累与ALD密切相关，因此许多研究已经研究了抗氧化剂的益处。最近的研究表明，多酚绿原酸（CGA）具有抗氧化特性和健康益处，例如降低了心血管疾病的相对风险以及对乙酰氨基酚毒性的保肝作用。但是，尚未详细研究CGA对ALD的保护作用。我们假设CGA通过其抗氧化特性在预防ALD中起作用。在这项研究中，我们研究了CGA在体内对肝损伤的保护作用。观察到由于降低的氧化应激水平，减少了酒精诱导的硬变，凋亡细胞死亡和纤维化。这些发现表明，CGA处理可以是通过抑制氧化应激来减轻ALD的有效方法。