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Dual‐Responsive Carbon Dot for pH/Redox‐Triggered Fluorescence Imaging with Controllable Photothermal Ablation Therapy of Cancer
ChemMedChem ( IF 3.4 ) Pub Date : 2018-06-14 , DOI: 10.1002/cmdc.201800202
Cheong A. Choi 1 , Jung Eun Lee 2 , Zihnil Adha Islamy Mazrad 3 , Young Kwang Kim 3 , Insik In 1, 4 , Ji Hoon Jeong 2 , Sung Young Park 1, 3
Affiliation  

Herein we describe fluorescence resonance energy transfer (FRET) for a pH/redox‐activatable fluorescent carbon dot (FNP) to realize “off–on” switched imaging‐guided controllable photothermal therapy (PTT). The FNP is a carbonized self‐crosslinked polymer that allows IR825 loading (FNP[IR825]) via hydrophobic interactions for cancer therapy. Fluorescence bioimaging was achieved by the internalization of FNP(IR825) into tumor cells, wherein glutathione (GSH) disulfide bonds are reduced, and benzoic imine groups are cleaved under acidic conditions. The release of IR825 from the FNP core in this system may be used to efficiently control PTT‐mediated cancer therapy via its photothermal conversion after near‐infrared (NIR) irradiation. In vitro and in vivo cellular uptake studies revealed efficient uptake of FNP(IR825) by tumor cells to treat the disease site. In this way we demonstrated in mice that our smart nanocarrier can effectively kill tumor cells under exposure to a NIR laser, and that the particles are biocompatible with various organs. This platform responds sensitively to the exogenous environment inside the cancer cells and may selectively induce the release of PTT‐mediated cytotoxicity. Furthermore, this platform may be useful for monitoring the elimination of cancer cells through the fluorescence on/off switch, which can be used for various applications in the field of cancer cell therapy and diagnosis.

中文翻译:

pH /氧化还原触发荧光成像的双响应碳点,可控的癌症光热消融治疗

本文中,我们描述了pH /氧化还原可激活的荧光碳点(FNP)的荧光共振能量转移(FRET),以实现“关闭”开关成像引导的可控光热疗法(PTT)。FNP是一种碳化的自交联聚合物,可通过疏水相互作用使IR825负载(FNP [IR825])用于癌症治疗。通过将FNP(IR825)内化到肿瘤细胞中来实现荧光生物成像,其中还原性谷胱甘肽(GSH)二硫键,并在酸性条件下裂解苯甲亚胺基。该系统中FNP核心释放的IR825可用于通过近红外(NIR)照射后的光热转化来有效控制PTT介导的癌症治疗。体外和体内细胞摄取研究表明,肿瘤细胞可有效摄取FNP(IR825),以治疗疾病部位。通过这种方式,我们在小鼠中证明了我们的智能纳米载体可以在暴露于NIR激光下有效杀死肿瘤细胞,并且该颗粒与各种器官具有生物相容性。该平台对癌细胞内的外源环境敏感,可以选择性诱导PTT介导的细胞毒性释放。此外,该平台可用于通过荧光开/关开关监测癌细胞的消除,该开关可用于癌细胞治疗和诊断领域的各种应用。并且这些颗粒与各种器官具有生物相容性。该平台对癌细胞内的外源环境敏感,可以选择性诱导PTT介导的细胞毒性释放。此外,该平台可用于通过荧光开/关开关监测癌细胞的消除,该开关可用于癌细胞治疗和诊断领域的各种应用。并且这些颗粒与各种器官具有生物相容性。该平台对癌细胞内的外源环境敏感,可以选择性诱导PTT介导的细胞毒性释放。此外,该平台可用于通过荧光开/关开关监测癌细胞的消除,该开关可用于癌细胞治疗和诊断领域的各种应用。
更新日期:2018-06-14
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