Aureochaeglobosins A–C (1–3), three novel [4 + 2] cycloaddition heterodimers of chaetoglobosin and aureonitol derivatives, were obtained from the culture of endophytic fungus Chaetomium globosum, representing the first adduct examples of chaetoglobosins. Their structures were elucidated by extensive spectroscopic analyses, single-crystal X-ray diffraction, and a modified Mosher’s method. Compounds 2 and 3 showed significant cytotoxicities against human MDA-MB-231 cancer cells with IC₅₀ values of 7.6 and 10.8 μM, respectively.

中文翻译：

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金葡球菌素A–C，球藻壳蜡球蛋白和金葡糖醇衍生物的三种[4 + 2]加合物

Aureochaeglobosins A-C（1 - 3），球毛壳菌素和aureonitol衍生物的三种新的[4 + 2]环加成的异源二聚体，从内生真菌的培养物中获得球毛壳菌，代表chaetoglobosins的第一加合物的例子。通过广泛的光谱分析，单晶X射线衍射和改进的Mosher方法阐明了它们的结构。化合物2和3对人MDA-MB-231癌细胞表现出明显的细胞毒性，IC ₅₀值分别为7.6和10.8μM。