The Cu(OAc)₂-catalyzed three-component reactions of o-aminophenols, acyl chlorides and 1,2-dichloroethane (DCE) have been established for the efficient synthesis of 3,4-dihydro-2H-benzo[b][1,4]oxazines (3,4-dihydro-1,4-benzoxazines). This method features advantages of the one-pot operation enabling N-acylation, CCl bond amidation and etherification, as well as the structural divergence of the synthesized products.

中文翻译：

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通过酰基氯，邻氨基苯酚和1,2-二氯乙烷的三组分反应精确合成3,4-二氢-1,4-苯并恶嗪

已经建立了Cu（OAc）₂催化的邻氨基苯酚，酰氯和1,2-二氯乙烷（DCE）的三组分反应，可有效合成3,4-二氢-2 H-苯并[ b ] [ 1,4]恶嗪（3,4-二氢-1,4-苯并恶嗪）。该方法的优点在于一锅操作的优点是能够进行N-酰化，C Cl键酰胺化和醚化，以及合成产物的结构差异。