Syntheses of epigallocatechin trimer, (epigallocatechin)₂-epicatechin and (epigallocatechin)₂-catechin were achieved. The key condensation to form the proanthocyanidin trimer derivatives was accomplished in a one-pot procedure using a dimeric epigallocatechin electrophile, which was prepared in situ by self-condensation of an epigallocatechin derivative, and an epigallocatechin, epicatechin, or catechin derivative as the nucleophile in the presence of a Lewis acid. The epigallocatechin monomer to trimer compounds containing a pyrogallol group significantly suppressed cell proliferation in PC-3 prostate cancer cells.

中文翻译：

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路易斯酸介导的一锅缩合反应合成表没食子儿茶素三聚体，（表没食子儿茶素）_2-表儿茶素和（表没食子儿茶素）_2-儿茶素及其在前列腺癌细胞中的抗肿瘤活性

合成了表没食子儿茶素三聚体，（表没食子儿茶素）_2-表儿茶素和（表没食子儿茶素）_2-儿茶素。形成原花青素三聚体衍生物的关键缩合反应是通过一锅法完成的，该方法使用了二聚表没食子儿茶素亲电体，该亲电体是通过自缩合表没食子儿茶素衍生物和表没食子儿茶素，表儿茶素或儿茶素衍生物作为亲核试剂原位制备的。路易斯酸的存在。含有邻苯三酚基团的三聚体的表没食子儿茶素单体显着抑制了PC-3前列腺癌细胞中的细胞增殖。