A copper-catalyzed Friedel–Crafts propargylation/hydroamination/aromatization sequence is described. In the presence of a catalytic amount of CuI, this sequential reaction can convert ethynyl benzoxazinanones and indoles into a diverse set of 3,3′-biindoles with high efficiency and selectivity. Moreover, the synthesis of other indole–heteroaryl molecules and the catalytic asymmetric formation of axially chiral 3,3′-biindoles are demonstrated.

中文翻译：

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通过铜催化的Friedel-Crafts炔丙基化/氢化/芳香化序列合成3,3'-联吲哚

描述了铜催化的Friedel-Crafts炔丙基化/加氢胺化/芳构化顺序。在催化量的CuI的存在下，该顺序反应可以高效高效地将乙炔基苯并恶嗪酮和吲哚转化为各种3,3'-联吲哚。此外，还证明了其他吲哚-杂芳基分子的合成和轴向手性3,3'-双吲哚的催化不对称形成。