Based on a thorough and critical analysis of the commercial crystal structure prediction studies of 41 pharmaceutical compounds, we conclude that for between 15 and 45% of all small-molecule drugs currently on the market the most stable experimentally observed polymorph is not the thermodynamically most stable crystal structure and that the appearance of the latter is kinetically hindered.

中文翻译：

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那里还有几例利托那韦病例？

根据对41种药物的商业晶体结构预测研究的全面而严格的分析，我们得出结论，对于目前市场上所有小分子药物中15％至45％之间，最稳定的实验观察到的多晶型物并不是热力学上最稳定的晶体结构，并且后者的出现在动力学上受到阻碍。