Research has shown that therapeutic sleep deprivation (SD) has rapid antidepressant effects in the majority of depressed patients. Investigation of factors preceding and accompanying these effects may facilitate the identification of the underlying biological mechanisms. This exploratory study aimed to examine clinical and genetic factors predicting response to SD and determine the impact of SD on illness course. Mood during SD was also assessed via visual analogue scale. Depressed inpatients (n = 78) and healthy controls (n = 15) underwent ~36 h of SD. Response to SD was defined as a score of ≤ 2 on the Clinical Global Impression Scale for Global Improvement. Depressive symptom trajectories were evaluated for up to a month using self/expert ratings. Impact of genetic burden was calculated using polygenic risk scores for major depressive disorder. In total, 72% of patients responded to SD. Responders and non-responders did not differ in baseline self/expert depression symptom ratings, but mood differed. Response was associated with lower age (p = 0.007) and later age at life-time disease onset (p = 0.003). Higher genetic burden of depression was observed in non-responders than healthy controls. Up to a month post SD, depressive symptoms decreased in both patients groups, but more in responders, in whom effects were sustained. The present findings suggest that re-examining SD with a greater focus on biological mechanisms will lead to better understanding of mechanisms of depression.

中文翻译：

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对治疗性睡眠剥夺的反应：对临床和遗传因素以及治疗后抑郁症状轨迹的自然研究。

研究表明，治疗性睡眠剥夺（SD）在大多数抑郁症患者中具有快速的抗抑郁作用。研究这些效应之前和伴随的因素可能有助于识别潜在的生物学机制。这项探索性研究旨在检查可预测对SD反应的临床和遗传因素，并确定SD对疾病进程的影响。SD期间的情绪也通过视觉模拟量表进行评估。抑郁症患者（n = 78）和健康对照（n = 15）接受了约36 h的SD。对SD的反应定义为临床总体印象量表中全球改善的评分≤2。使用自我/专家评分对抑郁症状的轨迹进行长达一个月的评估。使用多发性抑郁症的多基因风险评分来计算遗传负担的影响。总共有72％的患者对SD有反应。响应者和非响应者的基线自我/专家抑郁症状评分无差异，但情绪有所不同。反应与较低的年龄（p = 0.007）和较高的终生发病年龄（p = 0.003）相关。在无反应者中观察到抑郁症的遗传负担比健康对照者要高。在SD后的一个月内，两组患者的抑郁症状均有所减轻，但在疗效持续的应答者中，抑郁症状有所减轻。本研究结果表明，重新审视SD会更加关注生物学机制，这将有助于人们更好地了解抑郁症的机制。007）及终生发病年龄（p = 0.003）。在无反应者中观察到抑郁症的遗传负担比健康对照者要高。在SD后长达一个月的时间里，两组患者的抑郁症状均有所减轻，但在疗效持续的应答者中，抑郁症状有所减轻。本研究结果表明，重新审视SD会更加关注生物学机制，这将有助于人们更好地了解抑郁症的机制。007）及终生发病年龄（p = 0.003）。在无反应者中观察到抑郁症的遗传负担高于健康对照者。在SD后的一个月内，两组患者的抑郁症状均有所减轻，但在疗效持续的应答者中，抑郁症状有所减轻。本研究结果表明，重新审视SD会更加关注生物学机制，这将有助于人们更好地了解抑郁症的机制。