Bacterial resistance to antibiotics is a major public health problem and there is an urgent need to find new antimicrobial materials to circumvent the development of resistant pathogens. The aim of this work is to propose an efficient and versatile method for the elaboration of antimicrobial polymeric materials based on the simple dispersion of a low amount of high molecular weight (M_n > 20 000 g mol⁻¹) amphiphilic methacrylic copolymers prepared by nitroxide-mediated polymerization in different common organic matrices (here PS and PMMA). More precisely, after studying the influence of different copolymer parameters on their biological activity (the amount and type of comonomer (styrene or acrylonitrile), the architecture (random or diblock), and the type of cationic charge (permanent or not)), some selected candidates were dispersed in PS and PMMA matrices and were shown to efficiently turn these inactive materials into antibacterial ones without a significant hemolytic character. In particular, only 0.02 wt% of antimicrobial copolymers were sufficient to confer an activity against both Gram positive (B. subtilis) and Gram negative (E. coli) bacteria.

中文翻译：

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通过分散定义明确的两亲甲基丙烯酸SG1基共聚物来制备抗菌聚合物材料

细菌对抗生素的耐药性是一个主要的公共卫生问题，迫切需要寻找新的抗菌材料来规避耐药性病原体的发展。这项工作的目的是基于少量高分子量（M _n > 20 000 g mol ^-1）是在不同的常见有机基质（此处为PS和PMMA）中由硝基氧介导的聚合反应制备的两亲甲基丙烯酸共聚物。更精确地讲，在研究了不同共聚物参数对其生物学活性（共聚单体的数量和类型（苯乙烯或丙烯腈），结构（无规或二嵌段）和阳离子电荷的类型（永久性或非永久性））的影响后，一些选定的候选物分散在PS和PMMA基质中，并被证明可以有效地将这些非活性物质转变成抗菌物质，而没有明显的溶血特性。特别地，仅0.02重量％的抗微生物共聚物足以赋予针对革兰氏阳性（枯草芽孢杆菌）和革兰氏阴性（大肠杆菌）细菌的活性。