Pellynols M−O, cytotoxic polyacetylenic alcohols from a Niphates sp. marine sponge,Tetrahedron

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Pellynols M−O, cytotoxic polyacetylenic alcohols from a Niphates sp. marine sponge
Tetrahedron ( IF 2.1 ) Pub Date : 2018-05-16 , DOI: 10.1016/j.tet.2018.05.041
Jie Wang , Li-Yun Liu , Lei Liu , Kai-Xuan Zhan , Wei-Hua Jiao , Hou-Wen Lin

Three new polyacetylenic alcohols, pellynols M−O (1–3), along with two known ones, melyne A (4) and melyne B (5), were isolated from a Niphates sp. marine sponge collected off the South China Sea. The structures of new compounds were determined based on a combination of 1D and 2D NMR analysis, ESI-MSⁿ fragmentation, and chemical (ozonolysis) method. Their absolute configurations were assigned by modified Mosher's method. All the isolates showed potent cytotoxic activity against PC9 and HepG2 human cancer cell lines with IC₅₀ values of 2.9–7.6 μM.

更新日期：2018-05-16

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