Effect of Antiretroviral Therapy on Plasma Concentrations of Chloroquine and Desethyl-chloroquine,Clinical Infectious Diseases

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Effect of Antiretroviral Therapy on Plasma Concentrations of Chloroquine and Desethyl-chloroquine
Clinical Infectious Diseases ( IF 11.8 ) Pub Date : 2018-05-16 , DOI: 10.1093/cid/ciy405
Matthew M Ippolito _{1,

2,

3} , Jeffrey M Jacobson ₄ , Michael M Lederman ₅ , Markus Winterberg _{6,

7} , Joel Tarning _{6,

7} , Theresa A Shapiro _{1,

3} , Charles Flexner _{1,

2}

Affiliation

The effect of antiretroviral therapy (ART) on chloroquine and desethyl-chloroquine plasma concentrations was evaluated in clinical trial participants. Concentrations did not differ among participants receiving protease inhibitor–based ART (n = 9), efavirenz-based ART (n = 15), or other ART (n = 8) and those not receiving ART (n = 31). Efavirenz seemed to inhibit chloroquine desethylation.

中文翻译：

抗逆转录病毒疗法对氯喹和去乙基氯喹血浆浓度的影响

在临床试验参与者中评估了抗逆转录病毒疗法 (ART) 对氯喹和去乙基氯喹血浆浓度的影响。接受基于蛋白酶抑制剂的 ART (n = 9)、基于依非韦伦的 ART (n = 15) 或其他 ART (n = 8) 的参与者与未接受 ART (n = 31) 的参与者的浓度没有差异。依法韦仑似乎抑制了氯喹的去乙基化作用。

更新日期：2018-05-16

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