Exogenous nitric oxide (NO) represents an attractive antibacterial agent because of its ability to both disperse and directly kill bacterial biofilms while avoiding resistance. Due to the challenges associated with administering gaseous NO, NO‐releasing macromolecular scaffolds are developed to facilitate NO delivery. This progress report describes the rational design and application of NO‐releasing macromolecular scaffolds as antibacterial therapeutics. Special consideration is given to the role of the physicochemical properties of the NO storage vehicles on antibacterial or anti‐biofilm activity.

中文翻译：

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用于抗菌应用的释放一氧化氮的大分子支架

外源性一氧化氮（NO）是一种有吸引力的抗菌剂，因为它能够分散和直接杀死细菌生物膜，同时避免产生耐药性。由于与管理气态 NO 相关的挑战，开发了释放 NO 的大分子支架来促进 NO 的输送。本进展报告描述了释放 NO 的大分子支架作为抗菌疗法的合理设计和应用。特别考虑了 NO 存储载体的物理化学性质对抗菌或抗生物膜活性的作用。