Social and demographic changes across the world over the past 50 years have resulted in significant outbreaks of arboviruses such as dengue virus (DENV) and Zika virus (ZIKV). Despite the increased threat of infection, no approved drugs or fully protective vaccines are available to counteract the spread of DENV and ZIKV. The development of “broad‐spectrum” antivirals (BSAs) that target common components of multiple viruses can be a more effective strategy to limit the rapid emergence of viral pathogens than the classic “one‐bug/one‐drug” approach. Starting from previously identified multitarget DENV inhibitors, herein we report the identification of novel 2,6‐diaminopurine derivatives that are able to block the replication of both Zika virus and all serotypes of dengue virus (DENV 1–4) in infected cells.

中文翻译：

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通过功能化喹啉和2,6-二氨基嘌呤支架鉴定广谱登革热/寨卡病毒复制抑制剂

在过去的50年中，世界各地的社会和人口变化导致了诸如登革热病毒（DENV）和寨卡病毒（ZIKV）之类的虫媒病毒的大量爆发。尽管增加了感染威胁，但尚无批准的药物或完全保护性疫苗可抵消DENV和ZIKV的传播。与经典的“单虫/单药”方法相比，针对多种病毒常见成分的“广谱”抗病毒药（BSA）的开发可以成为一种限制病毒病原体快速出现的更有效策略。从先前确定的多靶点DENV抑制剂开始，本文报道了能够阻止Zika病毒和所有血清型登革热病毒（DENV 1-4）在感染细胞中复制的新型2,6-二氨基嘌呤衍生物的鉴定。