Nanoparticles have been widely studied as versatile platforms for in vivo imaging and therapy. However, their use to image and/or treat the brain is limited, as they are often unable to cross the blood–brain barrier (BBB). To overcome this problem, herein we report the use of focused ultrasound in vivo to successfully deliver DNA‐coated gold nanoparticles to specific locations in the brains of mice.

中文翻译：

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使用聚焦超声跨血脑屏障靶向递送DNA-Au纳米颗粒

纳米颗粒已被广泛研究为体内成像和治疗的通用平台。但是，由于它们通常无法穿越血脑屏障（BBB），因此它们在成像和/或治疗大脑方面的应用受到限制。为了克服这个问题，在此我们报道了体内聚焦超声的使用，以成功地将涂有DNA的金纳米颗粒递送到小鼠脑中的特定位置。