Mechanistic insight into the singlet oxygen-triggered expansion of hypoxia-responsive polymeric micelles†,Biomaterials Science

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Mechanistic insight into the singlet oxygen-triggered expansion of hypoxia-responsive polymeric micelles†
Biomaterials Science ( IF 6.6 ) Pub Date : 2018-05-15 00:00:00 , DOI: 10.1039/c8bm00369f
Lina Wang _{1,

2,

3,

4,

5} , Xiaoli Huang _{1,

2,

3,

4,

5} , Bingbing Wang _{1,

2,

3,

4,

5} , Jie Zhao _{1,

2,

3,

4,

5} , Xuliang Guo _{1,

2,

3,

4,

5} , Zheng Wang _{1,

2,

3,

4,

5} , Yanjun Zhao _{1,

2,

3,

4,

5}

Affiliation

Nitroimidazole-bearing nanomedicine has been popular as a hypoxia-responsive platform for on-demand drug delivery. We report the singlet oxygen-responsive property of nitroimidazole-containing micelles and the corresponding reaction mechanism, which would pave the way for developing a dual hypoxia- and singlet oxygen-sensitive drug delivery nanoplatform based on a simple nitroimidazole moiety.

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