Here we report an efficient Cu(I)-mediated C–H amination reaction with oximes as amino donors to introduce NH₂ groups directly. Various strongly coordinating heterocycles including quinoline, pyrimidine, pyrazine, pyrazole and triazole were tolerated well. The potential utility was further demonstrated in a late-stage modification of telmisartan (an antagonist for the angiotensin II receptor).

中文翻译：

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肟介导的铜介导的C–H胺化反应：向初级苯胺的过程中†

在这里，我们报告了一种以肟为氨基供体的Cu（I）介导的CH氨基化反应，可直接引入NH ₂基团。包括喹啉，嘧啶，吡嗪，吡唑和三唑在内的各种强配位杂环均具有良好的耐受性。在替米沙坦（血管紧张素II受体的拮抗剂）的后期修饰中进一步证明了这种潜在的效用。