Background and Aims

Gastric cancer (GC) is the fourth most common cancer and the fourth leading cause of cancer death worldwide. In some Asian countries, screening EGD has greatly improved the survival rate. However, patients’ discomfort and the need for sedation may limit adherence to screening programs. Previous studies have shown good tolerance and good agreement of magnetically controlled capsule gastroscopy (MCCG) with EGD. This study was designed to assess the application of MCCG in GC detection in an asymptomatic population.

Methods

In this observational cohort study, 3182 asymptomatic individuals undergoing MCCG in 99 participating medical examination centers from April to December 2016 were enrolled. Patients with ulcers and suspected malignancies were referred for gastroscopy and biopsy. The detection rate of GC and focal lesions were used to explore the application of MCCG in asymptomatic individuals.

Results

Seven patients (0.22%) were diagnosed with GC among the enrolled 3182 individuals, accounting for 0.74% (7/948) in patients over 50 years. No gender disparity was observed. EGD and biopsy confirmed adenocarcinoma in all cases of suspected malignancy. Benign polyps, gastric ulcers, and submucosal tumors were found in 10.4%, 4.9%, and 3.6% of patients, respectively. There was a trend for the prevalence of focal lesions to increase with age. MCCG examination proved to be safe.

Conclusions

MCCG can detect cancer and benign lesions and is safe and clinically feasible in a large population. Studies of its role in a screening program should be considered.

中文翻译：

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磁控胶囊胃镜在无症状人群中筛查胃癌

背景和目标

胃癌（GC）是全球第四大最常见的癌症，也是导致癌症死亡的第四大主要原因。在一些亚洲国家，筛查EGD可以大大提高生存率。但是，患者的不适和镇静的需要可能会限制对筛查程序的依从性。先前的研究表明，与EGD相比，磁控胶囊胃镜（MCCG）具有良好的耐受性和一致性。本研究旨在评估无症状人群中MCCG在GC检测中的应用。

方法

在这项观察性队列研究中，纳入了2016年4月至2016年12月在99个参与体检中心接受MCCG干预的3182名无症状个体。溃疡和疑似恶性肿瘤患者需进行胃镜检查和活检。GC和局灶性病变的检出率用于探讨MCCG在无症状个体中的应用。

结果

在登记的3182名患者中，有7名（0.22％）被诊断患有GC，占50岁以上患者的0.74％（7/948）。没有观察到性别差异。在所有怀疑为恶性肿瘤的病例中，EGD和活检证实为腺癌。分别在10.4％，4.9％和3.6％的患者中发现良性息肉，胃溃疡和粘膜下肿瘤。局灶性病变的患病率随年龄增长而增加。事实证明，MCCG检查是安全的。

结论

MCCG可以检测出癌症和良性病变，并且在大量人群中安全且在临床上可行。应该考虑对其在筛选程序中的作用进行研究。