Exposure to environmental risk factors during the prenatal and early childhood period can lead to physical and neurobehavioural developmental abnormalities^1,2 among children, which can persist into adulthood.^3,4 This finding emphasizes the importance of early environmental chemical exposure and suggests an underlying mechanism for its persisting effects during vulnerable periods.^5,6 Epigenetic processes have been suggested to mediate the lasting effects of environmental chemical exposure on the developmental trajectories of children.⁷ However, previous birth cohort studies have not thoroughly investigated the vulnerable periods of environmental exposure or the underlying mechanism for the lasting effects of environmental chemical exposure.^8–10

中文翻译：

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队列简介：儿童的环境与发展（EDC）研究：前瞻性儿童队列

暴露在产前和幼儿期环境风险因素导致的躯体和神经行为发育异常^{1 ，2}儿童中，它可以持续到成年期。^{3 ，4}这一发现强调了早期环境的化学品接触的重要性，并提出一个基本的机制，在易损期的持续影响。^{5 ，6}后生过程已建议调解对儿童的发展轨迹环境化学品暴露的持久影响。⁷然而，先前的出生队列研究尚未彻底调查环境暴露的脆弱时期或环境化学暴露的持久影响的潜在机制。^8-10