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Cohort profile: The Pharmacokinetic and clinical Observations in PeoPle over fiftY (POPPY) study
International Journal of Epidemiology ( IF 7.7 ) Pub Date : 2018-05-09 , DOI: 10.1093/ije/dyy072
Emmanouil Bagkeris 1 , Laura Burgess 2 , Patrick W Mallon 3 , Frank A Post 4 , Marta Boffito 5 , Memory Sachikonye 6 , Jane Anderson 7 , David Asboe 5 , Lucy Garvey 8 , Jaime Vera 9 , Ian Williams 1 , Margaret Johnson 10 , Daphne Babalis 2 , Davide De Francesco 1 , Alan Winston 8 , Caroline A Sabin 1
Affiliation  

The Pharmacokinetic and clinical Observations in PeoPle over fiftY (POPPY) Study was initiated in 2013 as the first large-scale study to assess clinical outcomes of people living with HIV (PLWH) over the age of 50 in England and Ireland. Discussions around the management of HIV as a chronic disease have been ongoing.1–5 However, some recent studies have suggested a possible acceleration of the ageing process in PLWH, with reported increases in the rates of several comorbidities including cardiovascular disease (CVD), cancers, cognitive disorders, end-stage liver and renal diseases, and frailty and fracture risk.6–10 The primary aims of the study are therefore: (i) to describe the burden of clinical conditions in older PLWH; ii) to investigate whether the burden of comorbidities is increased in PLWH compared with demographically similar HIV-negative people; and iii) to describe the outcomes of and resources required to treat some of the more common comorbidities expected to occur in older PLWH, to see whether these also appeared to differ between those with and without HIV. An additional, related, aim of the study is to investigate the impact of age on the concentrations of the different antiretroviral agents in the blood among PLWH. It is hoped that the study findings will contribute to the development and implementation of evidence-based recommendations for the optimal management and clinical monitoring of older PLWH. Study results will also contribute to the design of future studies for the treatment of diseases associated with ageing in this population. The study received ethical approval from the NHS Health Research Authority, National Research Ethics Service (NRES) Committee London. Ethics reference number is 12/LO/1409.

中文翻译:

队列概况:五十岁以上人群的药代动力学和临床观察(POPPY)研究

50 岁以上人群的药代动力学和临床观察 (POPPY) 研究于 2013 年启动,作为第一个评估英格兰和爱尔兰 50 岁以上 HIV 感染者 (PLWH) 临床结果的大规模研究。围绕将 HIV 作为一种慢性疾病进行管理的讨论一直在进行。1-5然而,最近的一些研究表明,PLWH 的衰老过程可能会加速,据报道,包括心血管疾病 (CVD)、癌症、认知障碍、终末期肝肾疾病和虚弱和骨折风险。6–10因此,该研究的主要目的是:(i) 描述老年 PLWH 的临床状况负担;ii) 调查与人口统计学相似的 HIV 阴性人群相比,PLWH 的合并症负担是否增加;iii) 描述治疗一些预计会在老年 PLWH 中发生的更常见合并症的结果和所需资源,看看这些合并症在感染和未感染 HIV 的人之间是否也存在差异。该研究的另一个相关目的是调查年龄对 PLWH 血液中不同抗逆转录病毒药物浓度的影响。希望研究结果将有助于制定和实施基于证据的建议,以优化老年 PLWH 的管理和临床监测。研究结果还将有助于设计未来的研究,以治疗该人群中与老龄化相关的疾病。该研究获得了 NHS 健康研究局、伦敦国家研究伦理服务 (NRES) 委员会的伦理批准。道德参考编号为 12/LO/1409。
更新日期:2018-05-09
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