Objective

The aim of this study was to synthesize, to characterize and to evaluate the effects on tubular occlusion of new monomer derived from cashew nut shell liquid (CNSL), also studying the effects of acid challenge (AC) on dentin surfaces treated with desensitizers.

Methods

The intermediary cardanol-epoxy (CNE) was synthesized through epoxidation of CNSL, followed by synthesis of cardanol-methacrylate-epoxy (CNME) through methacryloyl chloride esterification. Products were purified through chromatography column and characterized by Fourier transform infrared spectrometry and nuclear magnetic resonance. Resinous dentin desensitizers were formulated containing either unsaturated cardanol (CNU), CNE or CNME. Dentin disks were divided into seven groups: SL — Smear-layer, EDTA — EDTA-treated only, GLUMA — Gluma Desensitizer, OCB — One Coat Bond, CNU — CNU desensitizer, CNE — CNE desensitizer and CNME — CNME desensitizer. Dentinal fluid rate (DFF) was obtained using a Flodec equipment and tubular occlusion employing a scanning electron microscope (SEM), before and after AC. Data of DFF were submitted to two-way ANOVA and Tukey’s test (p < 0.05).

Results

GLUMA showed the lower reduction in DFF when compared to the other products, which were statistically similar. Even after AC, CNME presented the most homogenous and occluded surface, while CNE and CNU were partially removed, GLUMA was completely removed and OCB keep an occluded, but irregular surface.

Significance

CNME showed a great reduction of DFF and a homogenous occluded surface, suggesting that it may be a suitable and acid-resistant treatment option for dentine hypersensitivity.

中文翻译：

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腰果壳液（CNSL）衍生的新型甲基丙烯酸酯单体的合成，表征及其对牙本质小管阻塞的影响

客观的

这项研究的目的是合成，表征和评估腰果壳液（CNSL）衍生的新单体对肾小管闭塞的影响，还研究了酸激发（AC）对脱敏剂处理的牙本质表面的影响。

方法

通过CNSL的环氧化反应合成中间体腰果酚-环氧（CNE），然后通过甲基丙烯酰氯酯化反应合成腰果酚-甲基丙烯酸酯-环氧（CNME）。产物通过色谱柱纯化，并通过傅里叶变换红外光谱和核磁共振表征。配制的树脂牙本质脱敏剂包含不饱和腰果酚（CNU），CNE或CNME。牙本质盘分为七个组：SL-涂片层，仅EDTA-EDTA处理过的GLUMA-Gluma脱敏剂，OCB-一层涂层，CNU-CNU脱敏剂，CNE-CNE脱敏剂和CNME-CNME脱敏剂。在AC之前和之后，使用Flodec设备和使用扫描电子显微镜（SEM）的肾小管闭塞来获得牙本质液体速率（DFF）。

结果

与其他在统计上相似的产品相比，GLUMA显示出DFF的降低较低。即使在AC后，CNME仍呈现出最均匀且被遮挡的表面，而部分去除了CNE和CNU，GLUMA被完全去除，而OCB则保持了被遮挡但不规则的表面。

意义

CNME表现出DFF的大幅降低和均一的咬合表面，表明它可能是牙本质过敏的合适且耐酸的治疗选择。