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Synthesis of monodisperse chitosan nanoparticles
Food Hydrocolloids ( IF 10.7 ) Pub Date : 2018-10-01 , DOI: 10.1016/j.foodhyd.2018.05.010
David Joseph Sullivan , Malco Cruz-Romero , Timothy Collins , Enda Cummins , Joseph P. Kerry , Michael A. Morris

Abstract The objectives of this study were to evaluate the effects of the initial concentrations of chitosan (CS) and sodium tripolyphosphate (TPP), the CS:TPP mass ratio, the CS molecular weight (MW) and pH on the synthesis of CS nanoparticles (CS NPs). The particle size of the synthesised CS NPs was significantly affected (P 300 nm. While both native CS and CS NPs showed antimicrobial activity, no significant antimicrobial enhancement was observed for the NP form. The findings of this study have shown that monodisperse CS NPs can be obtained using a combination of bottom-up and top-down techniques and the unique physiochemical properties of these nanomaterials have the potential for applications in developing of antimicrobial active packaging materials.

中文翻译:

单分散壳聚糖纳米粒子的合成

摘要 本研究的目的是评估壳聚糖 (CS) 和三聚磷酸钠 (TPP) 的初始浓度、CS:TPP 质量比、CS 分子量 (MW) 和 pH 值对 CS 纳米粒子合成的影响。 CS NP)。合成的 CS NPs 的粒径受到显着影响(P 300 nm。虽然天然 CS 和 CS NPs 均显示出抗菌活性,但未观察到 NP 形式的显着抗菌增强。本研究结果表明,单分散 CS NPs 可以使用自下而上和自上而下技术相结合获得的纳米材料以及这些纳米材料独特的理化性质具有开发抗菌活性包装材料的潜力。
更新日期:2018-10-01
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