A new hollow fiber-liquid/solid phase microextraction for extraction of ginsenosides from a Chinese compound formula was established using Al₂O₃ nanoparticles as the adsorbent. The enhancement technique involved dispersing Al₂O₃ particles in n-butanol to fill the pores and lumen of a polyether sulfone membrane fiber. The optimum extraction conditions were as follows: n-butanol as the acceptor phase; total of 11 hollow fiber bars; extraction time of 50 min; methanol as the desorption solvent. The limits of detection for ginsenosides Rg₁, Re, and Rb₁ were 0.066, 0.306, and 0.400 μg mL⁻¹, respectively. The extraction recovery ranged from 88.61% to 94.29% with a relative standard deviation (RSD) < 6.30%. The proposed method was successfully applied to determine ginsenosides in a Yangshenguiling oral liquid and acceptable results were obtained.

中文翻译：

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Al ₂ O ₃纳米粒子作为吸附剂从口腔液中提取人参皂苷 的新型中空纤维液/固相微萃取

以Al ₂ O ₃纳米粒子为吸附剂，建立了一种新型的中空纤维-液相/固相微萃取技术，从中式化合物中提取人参皂苷。增强技术涉及将Al ₂ O ₃颗粒分散在正丁醇中以填充聚醚砜膜纤维的孔和内腔。最佳提取条件如下：正丁醇为受体相；正丁醇为受体相。总共11根中空纤维棒；提取时间为50分钟；甲醇为解吸溶剂。人参皂苷Rg ₁，Re和Rb ₁的检出限为0.066、0.306和0.400μgmL ^-1， 分别。萃取回收率从88.61％到94.29％，相对标准偏差（RSD）<6.30％。该方法成功地应用于洋生蕊灵口服液中人参皂苷的测定，结果令人满意。