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A tailor-made design of lipidic bicontinuous cubic matrices using amino acid ionic liquids as self-assembly media†
Molecular Systems Design & Engineering ( IF 3.6 ) Pub Date : 2018-05-07 00:00:00 , DOI: 10.1039/c8me00015h
Saki Fujiwara 1, 2, 3, 4, 5 , Hiroyuki Ohno 1, 2, 3, 4, 5 , Takahiro Ichikawa 1, 2, 3, 4, 5
Affiliation  

Lipidic bicontinuous cubic (QII) matrices are a class of liquid-crystalline matrices with three-dimensional (3D) continuity and periodicity. Owing to their unique nanostructures, they have attracted extensive attention as matrices for various bio-functional molecules such as enzymes, DNA, and membrane proteins. In the present study, we have succeeded in developing novel QII matrices using monoolein (MO) as an amphiphile and amino acid ionic liquids (AAILs) as solvents. By employing various AAILs, it has been found that the design of AAILs plays a key role in inducing QII liquid-crystalline phases. It is noteworthy that the excellent designability of AAILs enables the development of QII matrices showing various unique behaviors that are totally different from those of conventional QII matrices containing water as a solvent. For example, the AAIL-based QII matrices preserve the 3D nanostructures even in a low temperature region (lower than 0 °C). It is also possible to design QII matrices that preserve the nanostructures for a long period of time under conventional conditions using these AAILs; on the other hand, for water-based QII matrices, special conditions, such as relative humidity over 90%, are required for preserving the nanostructures; moreover, the cubic lattice constant can be controlled from 88 to 100 Å by tuning the AAILs. Herein, we not only present the results showing the advantages of the AAIL-based QII matrices in terms of their nanostructure design, but also describe our finding of a primary result showing that the AAIL-based QII matrices have great potential to be used as a matrix for some proteins to form secondary structures. Considering the recent significant progress made in the design of biocompatible ionic liquids, we believe that the present matrix design will lead to the development of a new technology for controlling the functions and behavior of various bio-functional molecules.

中文翻译:

使用氨基酸离子液体作为自组装介质的脂质双连续立方基质的量身定制设计

脂质双连续立方(Q II)矩阵是一类具有三维(3D)连续性和周期性的液晶矩阵。由于其独特的纳米结构,它们作为各种生物功能分子(例如酶,DNA和膜蛋白)的基质已引起广泛关注。在本研究中,我们已经成功地开发出了以单油精(MO)作为两亲物和氨基酸离子液体(AAILs)作为溶剂的新型Q II基质。通过使用各种AAIL,已经发现AAIL的设计在诱导Q II液晶相中起关键作用。值得注意的是,AAIL的出色可设计性使Q II的开发成为可能。表现出各种独特行为的基体与以水为溶剂的常规Q II基体完全不同。例如,基于AAIL的Q II矩阵即使在低温区域(低于0°C)中也可以保留3D纳米结构。还可以设计Q II矩阵,使用这些AIL在常规条件下长时间保留纳米结构。另一方面,对于水性Q II为了保存纳米结构,需要特殊条件的基质,例如相对湿度超过90%;此外,通过调整AAIL,可以将立方晶格常数控制在88至100Å之间。在此,我们不仅给出了基于AAIL的Q II矩阵在纳米结构设计方面的优势的结果,而且还描​​述了我们对基于AAIL的Q II矩阵具有巨大应用潜力的主要结果的发现。作为某些蛋白质形成二级结构的基质。考虑到最近在生物相容性离子液体设计方面取得的重大进展,我们认为目前的基质设计将导致控制各种生物功能分子的功能和行为的新技术的发展。
更新日期:2018-05-07
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