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Cytotoxic garcimultiflorones K–Q, lavandulyl benzophenones from Garcinia multiflora branches
Phytochemistry ( IF 3.8 ) Pub Date : 2018-08-01 , DOI: 10.1016/j.phytochem.2018.04.019
Zhao-Quan Wang , Xing-Yu Li , Dong-Bao Hu , Chun-Lin Long

Seven undescribed lavandulyl benzophenones garcimultiflorones K-Q, and fourteen known compounds were isolated from the CHCl3 soluble fraction of 95% EtOH extract of Garcinia multiflora branches. Their structures and absolute configurations were determined by spectroscopic techniques including NMR spectroscopy, MS analysis, and ECD calculations. Seven isolated compounds expect for garcimultiflorone L and garcimultiflorone O exhibited cytotoxic activities in vitro against five cancer cell lines (HL-60, A549, SMMC-7721, MCF-7, and SW480). It is worth mentioning that garcimultiflorone Q exhibited most significant cytotoxicities against five cancer cell lines with IC50 values ranging from 3.07-12.56 μM.

中文翻译:

细胞毒性 garcimultiflorones K-Q,来自藤黄枝条的薰衣草二苯甲酮

七种未描述的薰衣草基二苯甲酮 garcimultiflorones KQ 和十四种已知化合物从藤黄枝条的 95% EtOH 提取物的 CHCl3 可溶性部分中分离出来。它们的结构和绝对构型是通过光谱技术确定的,包括 NMR 光谱、MS 分析和 ECD 计算。除 garcimultiflorone L 和 garcimultiflorone O 外的七种分离化合物在体外对五种癌细胞系(HL-60、A549、SMMC-7721、MCF-7 和 SW480)表现出细胞毒性活性。值得一提的是,garcimultiflorone Q 对五种癌细胞系表现出最显着的细胞毒性,IC50 值范围为 3.07-12.56 μM。
更新日期:2018-08-01
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