Two novel γ-lactone derivatives, trigoheterophines A (1) and B (2), together with four known furan derivatives (3–6), were isolated from the stems and leaves of Trigonostemon heterophyllus. The structures of 1 and 2 were elucidated by extensive spectroscopic methods and the known compounds were identified by comparing with the data reported in literature. Among them, trigoheterophines A (1) and B (2) represent an unusual type of γ-lactone derivatives, possessing 21 carbon atoms on the carbon skeleton, and known compouds (3–6) are rare furan derivatives in the plant kingdom with diverse long-chain hydrocarbyl groups as substituents at C-4. All isolated compounds were evaluated for their antiproliferative activities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro. Compounds 1–6 showed significant antiproliferative effects against various human cancer cell lines with IC₅₀ values ranging from 0.28 to 12.06 μM. These findings suggest that the discoveries of these novel γ-lactone derivatives and furan derivatives with significant antiproliferative activities isolated from T. heterophyllus could be of great importance to the development of new anticancer agents.

两种新型γ -内酯衍生物，trigoheterophines A（1）和B（2）中，用四个已知呋喃衍生物（一起3 - 6），进行分离从茎叶三宝木属heterophyllus。通过广泛的光谱学方法阐明了1和2的结构，并通过与文献报道的数据进行比较来鉴定出已知化合物。其中，杂多酚A（1）和B（2）代表一种不寻常的γ-内酯衍生物，在碳骨架上具有21个碳原子，并且已知化合物（3 –6）是植物界中的稀有呋喃衍生物，其具有不同的长链烃基作为C-4的取代基。评估了所有分离的化合物在体外对五种人类癌细胞系HL-60，SMMC-7721，A-549，MCF-7和SW480的抗增殖活性。化合物1 - 6显示针对用IC的各种人癌细胞系显著抗增殖作用_50个值范围从0.28至12.06微米。这些发现表明，从异叶三叶草中分离出这些具有显着抗增殖活性的新型γ-内酯衍生物和呋喃衍生物的发现。 对于开发新的抗癌药物可能非常重要。