Fragment-based drug discovery (FBDD) is a highly interdisciplinary field, rich in ideas integrated from pharmaceutical sciences, chemistry, biology, and physics, among others. To enrich our understanding of the development of the field, we used bibliometric techniques to analyze 3642 publications in FBDD, complementing accounts by key practitioners. Mapping its core papers, we found the transfer of knowledge from academia to industry. Co-authorship analysis showed that university–industry collaboration has grown over time. Moreover, we show how ideas from other scientific disciplines have been integrated into the FBDD paradigm. Keyword analysis showed that the field is organized into four interconnected practices: library design, fragment screening, computational methods, and optimization. This study highlights the importance of interactions among various individuals and institutions from diverse disciplines in newly emerging scientific fields.

基于片段的药物发现（FBDD）是一个高度跨学科的领域，具有许多与药物科学，化学，生物学和物理学等相结合的思想。为了丰富我们对该领域的发展的了解，我们使用文献计量技术来分析FBDD中的3642种出版物，并补充了主要从业者的说法。通过映射其核心论文，我们发现知识已从学术界转移到工业界。共同作者分析表明，大学与产业之间的合作随着时间的推移而增长。此外，我们展示了如何将其他科学学科的思想整合到FBDD范式中。关键字分析表明，该领域分为四个相互联系的实践：库设计，片段筛选，计算方法和优化。