Emulsions are widely used in numerous fields. Therefore, there has been increasing interest in the development of new emulsification strategies toward emulsions with advanced functions. Herein we report the formation of diverse emulsions by host–guest interaction-mediated interfacial self-assembly under mild conditions. In this strategy, a hydrophilic diblock copolymer with one block containing β-cyclodextrin (β-CD) can assemble at the oil/water interface when its aqueous solution is mixed with an oil phase of benzyl alcohol (BA), by host–guest interactions between β-CD and BA. This results in significantly reduced interfacial tension and the formation of switchable emulsions with easily tunable droplet sizes. Furthermore, nanoemulsions with excellent stability are successfully prepared simply via vortexing. The self-assembled oil-in-water emulsions also show catastrophic phase inversion, which can generate stable bicontinuous phase and water-in-oil emulsions, thereby further extending phase structures that can be realized by this host–guest self-assembly approach. Moreover, the host–guest nanoemulsions are able to engineer different nanoparticles and microstructures as well as solubilize a diverse array of hydrophobic drugs and dramatically enhance their oral bioavailability. The host–guest self-assembly emulsification is facile, energetically friendly, and fully translatable to industry, therefore representing a conceptually creative approach toward advanced emulsions.

中文翻译：

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宿主-客体相互作用介导的自组装的多尺度和多功能乳液

乳液广泛用于许多领域。因此，人们对开发具有先进功能的乳液的新乳化策略越来越感兴趣。本文中，我们报道了在温和条件下，主客体相互作用介导的界面自组装形成了多种乳液。在这种策略中，当亲水性二嵌段共聚物的水溶液与苄醇（BA）的油相混合时，通过主客体相互作用，该亲水性嵌段共聚物可以与一个含β-环糊精（β-CD）的嵌段一起在油/水界面处组装。在β-CD和BA之间。这导致界面张力显着降低，并形成具有易于调节的液滴尺寸的可切换乳液。此外，仅通过涡旋就成功地制备了具有优异稳定性的纳米乳液。自组装的水包油乳液也显示出灾难性的相转化，可生成稳定的双连续相和油包水乳液，从而进一步扩展了可通过这种客-客自组装方法实现的相结构。此外，主客体纳米乳液能够工程化不同的纳米颗粒和微结构，并溶解多种疏水性药物，并显着提高其口服生物利用度。主客体自组装乳化剂易于操作，对能源友好，并且可以完全转化为工业用途，因此代表了一种针对高级乳液的概念创新方法。从而进一步扩展了这种主客体自组装方法可以实现的相结构。此外，主客体纳米乳液能够工程化不同的纳米颗粒和微结构，并溶解多种疏水性药物，并显着提高其口服生物利用度。主客体自组装乳化剂易于操作，对能源友好，并且可以完全转化为工业用途，因此代表了一种针对高级乳液的概念创新方法。从而进一步扩展了这种主客体自组装方法可以实现的相结构。此外，主客体纳米乳液能够工程化不同的纳米颗粒和微结构，并溶解多种疏水性药物，并显着提高其口服生物利用度。主客体自组装乳化剂易于操作，对能源友好，并且可以完全转化为工业用途，因此代表了一种针对高级乳液的概念创新方法。