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Effects of environmental stressors on lipid metabolism in aquatic invertebrates
Aquatic Toxicology ( IF 4.5 ) Pub Date : 2018-04-25 , DOI: 10.1016/j.aquatox.2018.04.016
Min-Chul Lee , Jun Chul Park , Jae-Seong Lee

Lipid metabolism is crucial for the survival and propagation of the species, since lipids are an essential cellular component across animal taxa for maintaining homeostasis in the presence of environmental stressors. This review aims to summarize information on the lipid metabolism under environmental stressors in aquatic invertebrates. Fatty acid synthesis from glucose via de novo lipogenesis (DNL) pathway is mostly well-conserved across animal taxa. The structure of free fatty acid (FFA) from both dietary and DNL pathway could be transformed by elongase and desaturase. In addition, FFA can be stored in lipid droplet as triacylglycerol, upon attachment to glycerol. However, due to the limited information on both gene and lipid composition, in-depth studies on the structural modification of FFA and their storage conformation are required. Despite previously validated evidences on the disturbance of the normal life cycle and lipid homeostasis by the environmental stressors (e.g., obesogens, salinity, temperature, pCO2, and nutrients) in the aquatic invertebrates, the mechanism behind these effects are still poorly understood. To overcome this limitation, omics approaches such as transcriptomic and proteomic analyses have been used, but there are still gaps in our knowledge on aquatic invertebrates as well as the lipidome. This paper provides a deeper understanding of lipid metabolism in aquatic invertebrates.



中文翻译:

环境胁迫对水生无脊椎动物脂质代谢的影响

脂类代谢对于物种的生存和繁殖至关重要,因为脂类是整个动物类群中在环境应激源存在下维持体内动态平衡所必需的细胞成分。这篇综述旨在总结有关环境压力在水生无脊椎动物中脂质代谢的信息。从头开始通过葡萄糖合成脂肪酸脂肪形成(DNL)途径在整个动物类群中都保存得很好。来自膳食和DNL途径的游离脂肪酸(FFA)的结构可以通过延长酶和去饱和酶转化。另外,FFA可以在附着于甘油时以三酰基甘油的形式储存在脂质滴中。然而,由于有关基因和脂质组成的信息有限,因此需要对FFA的结构修饰及其存储构象进行深入研究。尽管先前已验证了环境应激因素(例如,致肥胖物,盐度,温度,p CO 2)对正常生命周期和脂质体内稳态的干扰,和营养物质)中,这些作用背后的机制仍知之甚少。为了克服这一限制,已经使用了诸如转录组学和蛋白质组学分析之类的组学方法,但是我们对水生无脊椎动物和脂质组学的认识仍然存在差距。本文对水生无脊椎动物的脂质代谢提供了更深入的了解。

更新日期:2018-04-25
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