There is considerable interest in the use of synthetic miRNA mimics (or inhibitors) as potential therapeutic agents in pulmonary vascular disease; however, the optimal delivery method to achieve high efficiency, selective lung targeting has not been determined. Here, we sought to investigate the relative merits of different lung-targeted strategies for delivering miRNA mimics in rats.

中文翻译：

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MicroRNA模拟物的肺靶向递送策略的系统评估

使用合成的miRNA模拟物（或抑制剂）作为肺血管疾病的潜在治疗剂引起了极大的兴趣。然而，尚未确定实现高效率，选择性肺靶向的最佳递送方法。在这里，我们试图调查在大鼠中传递miRNA模拟物的不同肺靶向策略的相对优点。