Rationale: Mxi1 is regarded as a potential tumor suppressor protein that antagonizes the transcriptional activity of proto-oncogene Myc. However, the clinical significances and underlying mechanisms by which Mxi1 is regulated in lung cancer remain poorly understood.

中文翻译：

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β-Trcp泛素连接酶的S6K1磷酸化依赖性Mxi1降解促进肺癌Myc激活和抗辐射性

理由： Mxi1被认为是一种潜在的抑癌蛋白，可拮抗原癌基因Myc的转录活性。但是，对肺癌中Mxi1进行调节的临床意义和潜在机制仍知之甚少。