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Crystallization at Solvent Interfaces Enables Access to a Variety of Cocrystal Polymorphs and Hydrates
Crystal Growth & Design ( IF 3.8 ) Pub Date : 2018-04-30 00:00:00 , DOI: 10.1021/acs.cgd.8b00114
Stefan J. Diez 1 , Mark D. Eddleston 1 , Mihails Arhangelskis 1 , Marie Milbled 1 , Matthias J. Müller 1 , Andrew D. Bond 1 , Dejan-Krešimir Bučar 2 , William Jones 1
Affiliation  

A crystal growth technique, interfacial cocrystallization, is demonstrated to be a simple and effective method for preparing multicomponent crystal forms. The technique is based on the generation of a liquid–liquid interface between two immiscible solutions of cocrystal-forming compounds, and its utility is demonstrated through the preparation of polymorphs and hydrates of caffeine cocrystals, involving three different hydroxy-2-naphthoic acids, including the formation of some with unexpected compositions.

中文翻译:

在溶剂界面上结晶可访问多种共晶多晶型物和水合物

晶体生长技术,界面共结晶,被证明是制备多组分晶体形式的一种简单有效的方法。该技术基于在共晶形成化合物的两种不混溶溶液之间形成液-液界面,并且通过制备咖啡因共晶的多晶型物和水合物来证明其实用性,其中涉及三种不同的羟基-2-萘甲酸,包括形成一些意想不到的成分。
更新日期:2018-04-30
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