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Ring-through-ring molecular shuttling in a saturated [3]rotaxane
Nature Chemistry ( IF 21.8 ) Pub Date : 2018-04-30 , DOI: 10.1038/s41557-018-0040-9
Kelong Zhu , Giorgio Baggi , Stephen J. Loeb

Mechanically interlocked molecules such as rotaxanes and catenanes comprise two or more components whose motion relative to each other can be controlled. A [2]rotaxane molecular shuttle, for example, consists of an axle bearing two recognition sites and a single macrocyclic wheel that can undergo a to-and-fro motion along the axle—shuttling between the recognition sites. The ability of mechanically interlocked molecules to undergo this type of large-amplitude change is the core mechanism behind almost every interlocked molecular switch or machine, including sophisticated mechanical systems such as a molecular elevator and a peptide synthesizer. Here, as a way to expand the scope of dynamics possible at the molecular level, we have developed a molecular shuttling mechanism involving the exchange of rings between two recognition sites in a saturated [3]rotaxane (one with no empty recognition sites). This was accomplished by passing a smaller ring through a larger one, thus achieving ring-through-ring molecular shuttling.



中文翻译:

饱和[3]轮烷中的环环式分子穿梭

机械互锁的分子,例如轮烷和链烷烃包含两个或多个组分,其相对于彼此的运动可被控制。例如,[2]轮烷分子穿梭系统由一个带有两个识别位点的轴和一个可以沿着该轴往复运动(在识别位点之间穿梭)的单个大环轮组成。机械连锁分子经历这种大幅度变化的能力是几乎每个连锁分子开关或机器(包括复杂的机械系统,例如分子升降器和肽合成仪)背后的核心机制。在这里,作为扩大在分子水平上可能的动力学范围的一种方法,我们已经开发了一种分子穿梭机制,涉及在饱和[3]轮烷中的两个识别位点之间交换环(一个没有空的识别位点)。这是通过使较小的环穿过较大的环来完成的,从而实现环通环分子穿梭。

更新日期:2018-05-01
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