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Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population
Ophthalmology ( IF 13.7 ) Pub Date : 2018-04-30


Purpose

To investigate systemic and ocular determinants of peripapillary retinal nerve fiber layer thickness (pRNFLT) in the European population.

Design

Cross-sectional meta-analysis.

Participants

A total of 16 084 European adults from 8 cohort studies (mean age range, 56.9±12.3–82.1±4.2 years) of the European Eye Epidemiology (E3) consortium.

Methods

We examined associations with pRNFLT measured by spectral-domain OCT in each study using multivariable linear regression and pooled results using random effects meta-analysis.

Main Outcome Measures

Determinants of pRNFLT.

Results

Mean pRNFLT ranged from 86.8±21.4 μm in the Rotterdam Study I to 104.7±12.5 μm in the Rotterdam Study III. We found the following factors to be associated with reduced pRNFLT: Older age (β = –0.38 μm/year; 95% confidence interval [CI], –0.57 to –0.18), higher intraocular pressure (IOP) (β = –0.36 μm/mmHg; 95% CI, –0.56 to –0.15), visual impairment (β = –5.50 μm; 95% CI, –9.37 to –1.64), and history of systemic hypertension (β = –0.54 μm; 95% CI, –1.01 to –0.07) and stroke (β = –1.94 μm; 95% CI, –3.17 to –0.72). A suggestive, albeit nonsignificant, association was observed for dementia (β = –3.11 μm; 95% CI, –6.22 to 0.01). Higher pRNFLT was associated with more hyperopic spherical equivalent (β = 1.39 μm/diopter; 95% CI, 1.19–1.59) and smoking (β = 1.53 μm; 95% CI, 1.00–2.06 for current smokers compared with never-smokers).

Conclusions

In addition to previously described determinants such as age and refraction, we found that systemic vascular and neurovascular diseases were associated with reduced pRNFLT. These may be of clinical relevance, especially in glaucoma monitoring of patients with newly occurring vascular comorbidities.



中文翻译:

在欧洲眼流行病学(E3)人群中,乳头周围视网膜神经纤维层厚度的系统和眼部决定因素

目的

目的调查欧洲人群中乳头周围视网膜神经纤维层厚度(pRNFLT)的系统和眼部决定因素。

设计

横断面荟萃分析。

参加者

来自欧洲眼流行病学(E3)联盟的8个队列研究(平均年龄范围,56.9±12.3–82.1±4.2岁)中的1684名欧洲成年人。

方法

在每项研究中,我们使用多变量线性回归分析了与通过光谱域OCT测量的pRNFLT的关联,并使用随机效应荟萃分析汇总了结果。

主要观察指标

pRNFLT的决定因素。

结果

pRNFLT的平均范围从鹿特丹研究I的86.8±21.4μm到鹿特丹研究III的104.7±12.5μm。我们发现以下因素与pRNFLT降低有关:年龄较大(β= –0.38μm/年; 95%置信区间[CI],-0.57至–0.18),眼压(IOP)较高(β= –0.36μm / mmHg; 95%CI,–0.56至–0.15),视力障碍(β= –5.50μm; 95%CI,–9.37至–1.64),和系统性高血压病史(β= –0.54μm; 95%CI, –1.01至–0.07)和行程(β= –1.94μm; 95%CI,–3.17至–0.72)。痴呆症有相关性提示(尽管不显着)(β= –3.11μm; 95%CI,–6.22至0.01)。较高的pRNFLT与远视球形当量(β= 1.39μm/屈光度; 95%CI,1.19–1.59)和吸烟(与不吸烟者相比,β= 1.53μm; 95%CI,1.00–2.06)相关。

结论

除了先前描述的决定因素(例如年龄和屈光度)外,我们还发现全身性血管和神经血管疾病与pRNFLT降低有关。这些可能与临床有关,尤其是在青光眼监测新出现的血管合并症的患者中。

更新日期:2018-04-30
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