Skin and skin appendages protect the body from harmful environment and prevent internal organs from dehydration. Superficial epidermal wounds usually heal without scarring, however, deep dermal wound healing commonly ends up with nonfunctioning scar formation with substantial loss of skin appendage. Wound healing is one of the most complex dynamic biological processes, during which a cascade of biomolecules combine with stem cell influx and matrix synthesis and synergistically contribute to wound healing at all levels. Although many approaches have been investigated to restore complete skin, the clinically effective therapy is still unavailable and the regeneration of perfect skin still remains a significant challenge. The complete mechanism behind scarless skin regeneration still requires further investigation. Fortunately, recent advancement in regenerative medicine empowers us more than ever to restore tissue in a regenerative manner. Many studies have elucidated and reviewed the contribution of stem cells and growth factors to scarless wound healing. This article focuses on recent advances in scarless wound healing, especially strategies to engineer pro‐regenerative scaffolds to restore damaged skin in a regenerative manner.

中文翻译：

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用于无创伤口愈合的工程专业再生水凝胶

皮肤和皮肤附件可保护人体免受有害环境的侵害，并防止内部器官脱水。浅表皮伤口通常可以愈合而不会留下疤痕，但是，深层皮肤伤口的愈合通常会导致无功能的疤痕形成，并严重丧失皮肤附件。伤口愈合是最复杂的动态生物学过程之一，在此过程中，一系列生物分子与干细胞流入和基质合成相结合，并在各个层面上协同促进伤口愈合。尽管已经研究了许多方法来恢复完整的皮肤，但是仍然没有临床有效的疗法，而完美皮肤的再生仍然是一个重大挑战。无疤的皮肤再生背后的完整机制仍需进一步研究。幸运的是，再生医学的最新进展使我们比以往任何时候都更有能力以再生的方式恢复组织。许多研究已经阐明并回顾了干细胞和生长因子对无创伤口愈合的贡献。本文重点介绍了无疤伤口愈合的最新进展，特别是工程改造可再生支架以再生方式恢复受损皮肤的策略。