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An enhanced Nonenzymatic Electrochemical Glucose Sensor Based on Copper‐Palladium Nanoparticles Modified Glassy Carbon Electrodes
Electroanalysis ( IF 3 ) Pub Date : 2018-04-18 , DOI: 10.1002/elan.201800017
Zhan-Hong Li 1, 2 , Xue-Ling Zhao 1, 2 , Xin-Cheng Jiang 1 , Yi-Hua Wu 1, 2 , Cheng Chen 1, 2 , Zhi-Gang Zhu 1, 2 , Jean-Louis Marty 3 , Qing-Song Chen 4
Affiliation  

Novel copper‐palladium nanoparticles modified glassy carbon electrodes (Cu−Pd/GC) with enhanced nonenzymatic sensing for glucose were facilely prepared by one‐step electrodeposition. The structure and composition of the prepared nanoparticles were characterized by XRD, SEM, TEM and EDS, respectively. The electrode modified process was characterized by electrochemical impedance spectroscopy. Cyclic voltammetry and chronoamperometric experiments were used to evaluate the electrocatalytic activities of the electrodes toward glucose. The surface morphology and the electrocatalytic activities of Cu−Pd/GC was compared to Pd and Cu nanoparticles modified glassy carbon electrodes (Pd/GC and Cu/GC), respectively. Thanks to homogeneous distribution of Cu−Pd nanoparticles and the synergistic effect of Cu and Pd atoms, Cu−Pd/GC exhibited the highest sensitivity (298 μA mM−1 cm−2) and the widest linear amperometric response (0.01 mM to 9.6 mM, R2=0.996) toward glucose compared to Pd/GC and Cu/GC. The detection limit of Cu−Pd/GC was 0.32 μM (S/N=3). In addition, the as‐prepared Cu−Pd/GC glucose sensor also exhibited exceptional capabilities of anti‐interference, reproducibility and long‐term stability. The as‐prepared sensor was also evaluated for determination of glucose concentration in human blood serum samples, which exhibited high reliability and accuracy, having great potential in clinical application.

中文翻译:

基于铜钯纳米粒子修饰的玻碳电极的增强型非酶电化学葡萄糖传感器

通过一步电沉积可以轻松地制备新型的铜钯纳米粒子修饰的玻碳电极(Cu-Pd / GC),具有增强的非酶葡萄糖传感能力。分别通过XRD,SEM,TEM和EDS对制备的纳米颗粒的结构和组成进行了表征。电极修饰的过程通过电化学阻抗谱进行了表征。循环伏安法和计时电流法实验用于评估电极对葡萄糖的电催化活性。将Cu-Pd / GC的表面形态和电催化活性分别与Pd和Cu纳米粒子修饰的玻碳电极(Pd / GC和Cu / GC)进行了比较。由于Cu-Pd纳米粒子的均匀分布以及Cu和Pd原子的协同作用,-1  cm -2)和与Pd / GC和Cu / GC相比,对葡萄糖的线性响应最大(0.01 mM至9.6 mM,R 2 = 0.996)。Cu-Pd / GC的检出限为0.32μM(S / N = 3)。此外,所制备的Cu-Pd / GC葡萄糖传感器还具有出色的抗干扰能力,可重复性和长期稳定性。还对准备好的传感器进行了测定人血清样本中葡萄糖浓度的评估,该样本具有很高的可靠性和准确性,在临床应用中具有很大的潜力。
更新日期:2018-04-18
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